Key Properties of Monosodium Phosphate
| Product Name: | Monosodium Phosphate |
| Synonyms: | Sodium dihydrogen phosphate, MSP |
| CAS No: | 7558-80-7 |
| Chemical Formula: | NaH₂PO₄ /NaH₂PO₄·H₂O/NaH₂PO₄·2H₂O |
| Grade: | IP / USP |
| Appearance: | White, crystalline powder or granules |
| Molar Mass: | 119.98 g/mol, 138.00 g/mol, 156.00 g/mol |
| Solubility: | Freely soluble in water, insoluble in alcohol |
| Melting Point: | 190°C (Decomposes) |
Inquiry
WhatsappMonosodium Phosphate Manufacturing process
Step 1: Raw Material Selection
- High-purity phosphoric acid and sodium carbonate are selected.
- Raw materials undergo strict quality checks for purity.
Step 2: Chemical Reaction & Processing
- Phosphoric acid reacts with sodium carbonate to form Monosodium Phosphate solution.
- The solution is filtered and refined to remove impurities.
Step 3: Crystallization & Drying
- The solution is evaporated, crystallized, and dried to achieve the required purity.
Step 4: Quality Control & Testing
- The product is tested for assay, solubility, moisture content, and pH as per IP/BP/USP standards.
Step 5: Packaging & Storage
- Packed in HDPE bags or fiber drums to prevent contamination.
- Stored in a cool, dry place to maintain stability.
Monosodium Phosphate Applications
Pharmaceutical Applications
Buffering Agent in Pharmaceutical Formulations
Suitable pharmaceutical grades of Monosodium Phosphate may be used as a buffering agent in selected pharmaceutical formulations. It helps control and maintain the required pH where phosphate-based buffer systems are appropriate.
pH Adjustment and Control
Monosodium Phosphate may be used for pH adjustment in suitable pharmaceutical formulations and manufacturing processes. It is commonly used with dibasic phosphate salts to prepare phosphate buffer systems.
Phosphate Source in Formulations
Monosodium Phosphate can serve as a source of phosphate ions in selected pharmaceutical formulations where phosphate is required as part of the formulation system.
Pharmaceutical Processing
Pharmaceutical manufacturers may use Monosodium Phosphate in suitable processing applications involving buffering, pH control or phosphate-based formulation requirements.
Food and Beverage Applications
Acidity Regulator and Buffer
Food-grade Monosodium Phosphate may function as an acidity regulator and buffering agent in suitable food and beverage formulations.
pH Control in Food Processing
It may be used to adjust or maintain pH during selected food-processing operations where phosphate-based control is required.
Mineral and Phosphate Source
Monosodium Phosphate may be incorporated into selected food formulations as a source of phosphate ions, subject to applicable food regulations and product requirements.
Laboratory and Analytical Applications
Phosphate Buffer Preparation
Monosodium Phosphate is widely used in laboratories to prepare phosphate buffer solutions, often in combination with dibasic sodium phosphate.
Analytical Reagent
It is used as a laboratory reagent in analytical, biochemical and research applications where phosphate ions or controlled pH conditions are required.
Biochemical and Research Applications
Monosodium Phosphate may be used in selected biochemical, microbiological and research procedures involving phosphate-buffered systems.
Chemical and Industrial Applications
Buffering and pH Control
Monosodium Phosphate may be used in selected chemical processes where phosphate buffering or pH adjustment is required.
Phosphate Source in Chemical Processing
It can serve as a phosphate source in selected chemical reactions and formulation systems.
Specialty Formulation Applications
Monosodium Phosphate may be incorporated into specialty chemical formulations where phosphate functionality, buffering or controlled acidity is required.
Water and Process Applications
Water-Treatment and Process Systems
Phosphate salts, including Monosodium Phosphate, may be used in selected water-treatment and industrial process systems where phosphate chemistry or pH control is required. Suitability depends on the specific process conditions and regulatory requirements.
Monosodium Phosphate Specifications
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White, crystalline powder or granules |
| 2 | Assay (Purity) | Not less than 98.0% |
| 3 | Loss on Drying | Not more than 2.0% |
| 4 | pH (1% solution) | 4.1 – 4.7 |
| 5 | Solubility | Freely soluble in water |
| 6 | Chloride (Cl⁻) | Not more than 50 ppm |
| 7 | Sulphate (SO₄²⁻) | Not more than 150 ppm |
| 8 | Heavy Metals | Not more than 10 ppm |
| 9 | Iron (Fe) | Not more than 5 ppm |
| 10 | Lead (Pb) | Not more than 3 ppm |
| 11 | Arsenic (As) | Not more than 2 ppm |
| 12 | Residue on Ignition | Not more than 0.5% |
Monosodium Phosphate Anhydrous IP Specification
Download Monosodium Phosphate Anhydrous IP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | A white powder or colourless crystals. |
| 2 | Solubility | Freely soluble in water; practically insoluble in Alcohol. |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | pH | 4.1 to 4.5 |
| 6 | Insoluble Substances | Not more than 0.2% |
| 7 | Chlorides | Not more than 140 ppm |
| 8 | Sulphates | Not more than 0.15% |
| 9 | Aluminium, Calcium and Related Elements | Passes the test |
| 10 | Arsenic | Not more than 8 ppm |
| 11 | Heavy Metals | Not more than 20 ppm |
| 12 | Water | Not more than 2.0% |
| 13 | Assay (On anhydrous basis) | Not less than 98.00% and not more than 103.00% |
Monosodium Phosphate Monohydrate IP Specification
Download Monosodium Phosphate Monohydrate IP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | A white powder or colourless crystals. |
| 2 | Solubility | Freely soluble in water; practically insoluble in Alcohol. |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | pH | 4.1 to 4.5 |
| 6 | Insoluble Substances | Not more than 0.2% |
| 7 | Chlorides | Not more than 140 ppm |
| 8 | Sulphates | Not more than 0.15% |
| 9 | Aluminium, Calcium and Related Elements | Passes the test |
| 10 | Arsenic | Not more than 8 ppm |
| 11 | Heavy Metals | Not more than 20 ppm |
| 12 | Water | 10.00% to 15.00% |
| 13 | Assay (On anhydrous basis) | Not less than 98.00% and not more than 103.00% |
Monosodium Phosphate Dihydrate IP Specification
Download Monosodium Phosphate Dihydrate IP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | A white powder or colourless crystals. |
| 2 | Solubility | Freely soluble in water; practically insoluble in Alcohol. |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | pH | 4.1 to 4.5 |
| 6 | Insoluble Substances | Not more than 0.2% |
| 7 | Chlorides | Not more than 140 ppm |
| 8 | Sulphates | Not more than 0.15% |
| 9 | Aluminium, Calcium and Related Elements | Passes the test |
| 10 | Arsenic | Not more than 8 ppm |
| 11 | Heavy Metals | Not more than 20 ppm |
| 12 | Water | 18.00% to 26.50% |
| 13 | Assay (On anhydrous basis) | Not less than 98.00% and not more than 103.00% |
Monosodium Phosphate Anhydrous USP Specification
Download Monosodium Phosphate Anhydrous USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | A white powder or colourless crystals. |
| 2 | Solubility | Freely soluble in water; practically insoluble in Alcohol. |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | Insoluble Substances | Not more than 0.2% |
| 6 | Chloride | Not more than 0.14% |
| 7 | Sulfate | Not more than 0.15% |
| 8 | Aluminium, Calcium and Related Elements | Passes the test |
| 9 | Arsenic | Not more than 8 ppm |
| 10 | pH | 4.1 to 4.5 |
| 11 | Water | Less than 2.0% |
| 12 | Assay (On anhydrous basis) | Not less than 98.00% to not more than 103.00% |
Monosodium Phosphate Monohydrate USP Specification
Download Monosodium Phosphate Monohydrate USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | A white powder or colourless crystals. |
| 2 | Solubility | Freely soluble in water; practically insoluble in Alcohol. |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | Insoluble Substances | Not more than 0.2% |
| 6 | Chloride | Not more than 0.14% |
| 7 | Sulfate | Not more than 0.15% |
| 8 | Aluminium, Calcium and Related Elements | Passes the test |
| 9 | Arsenic | Not more than 8 ppm |
| 10 | pH | 4.1 to 4.5 |
| 11 | Water | 10.00% to 15.00% |
| 12 | Assay (On anhydrous basis) | Not less than 98.00% to not more than 103.00% |
Monosodium Phosphate Dihydrate USP Specification
Download Monosodium Phosphate Dihydrate USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | A white powder or colourless crystals. |
| 2 | Solubility | Freely soluble in water; practically insoluble in Alcohol. |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | Insoluble Substances | Not more than 0.2% |
| 6 | Chloride | Not more than 0.14% |
| 7 | Sulfate | Not more than 0.15% |
| 8 | Aluminium, Calcium and Related Elements | Passes the test |
| 9 | Arsenic | Not more than 8 ppm |
| 10 | pH | 4.1 to 4.5 |
| 11 | Water | 18.00% to 26.50% |
| 12 | Assay (On anhydrous basis) | Not less than 98.00% to not more than 103.00% |
Note: Additional test to be carried out as per customer requirements.
Monosodium Phosphate Packing and Storage condition
Packing & Storage:
- Packed in 25 kg / 50 kg HDPE bags with inner LDPE liner for moisture protection.
- Available in fiber drums or plastic drums for high-purity grades.
- Bulk packaging in jumbo bags (500 kg – 1000 kg) available upon request.
- Storage Conditions: Store in a cool, dry, and well-ventilated area away from direct sunlight.
Why Choose Chemignition for
Monosodium Phosphate Supply?
Quality Assurance
Grade Compliance
Monosodium Phosphate is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
Large-Scale Manufacturing and Export
Grade Compliance
Monosodium Phosphate is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
