Key Properties of Disodium Phosphate
| Product Name: | Disodium Phosphate |
| Synonyms: | Sodium Hydrogen Phosphate, DSP |
| CAS No: | 7558-79-4 |
| Chemical Formula: | Na₂HPO₄ |
| Grade: | IP / BP / USP |
| Appearance: | White, crystalline powder or granules |
| Molar Mass: | 141.96 g/mol |
| Solubility: | Freely soluble in water, insoluble in alcohol |
| Melting Point: | Na₂HPO₄ (anhydrous) decomposes upon heating |
Inquiry
WhatsappDisodium Phosphate Manufacturing process
Step 1: Raw Material Selection
- High-purity phosphoric acid and sodium carbonate are selected.
- Raw materials undergo strict quality checks for purity.
Step 2: Chemical Reaction & Processing
- Phosphoric acid reacts with sodium carbonate to form Disodium Phosphate solution.
- The solution is filtered and refined to remove impurities.
Step 3: Crystallization & Drying
- The solution is evaporated, crystallized, and dried to achieve the required purity.
Step 4: Quality Control & Testing
- The product is tested for assay, solubility, moisture content, and pH as per IP/BP/USP standards.
Step 5: Packaging & Storage
- Packed in HDPE bags or fiber drums to prevent contamination.
- Stored in a cool, dry place to maintain stability.
Disodium Phosphate Applications
Pharmaceutical Applications
Buffering Agent in Pharmaceutical Formulations
Suitable pharmaceutical grades of Disodium Phosphate may be used as a buffering agent in selected pharmaceutical formulations. It helps control and maintain the required pH where phosphate-based buffer systems are appropriate.
pH Adjustment and Control
Disodium Phosphate may be used for pH adjustment and control in suitable pharmaceutical formulations and manufacturing processes. It is commonly combined with monobasic phosphate salts to prepare phosphate buffer systems.
Phosphate Source in Pharmaceutical Formulations
Disodium Phosphate can serve as a source of phosphate ions in selected pharmaceutical preparations where phosphate is required as part of the formulation.
Pharmaceutical Processing
Pharmaceutical manufacturers may use Disodium Phosphate in suitable processing applications involving buffering, pH adjustment or phosphate-based formulation requirements.
Food and Beverage Applications
Acidity Regulation and Buffering
Food-grade Disodium Phosphate may function as an acidity regulator and buffering agent in suitable food and beverage formulations, helping manufacturers maintain the required pH.
Emulsifying and Stabilizing Applications
Disodium Phosphate may be used in selected food formulations where phosphate functionality contributes to emulsification, stability or product consistency.
Food Processing Applications
Food manufacturers may use Disodium Phosphate in suitable processed-food applications where pH control, phosphate functionality or formulation stability is required. The grade and usage level should comply with applicable food regulations.
Laboratory and Analytical Applications
Phosphate Buffer Preparation
Disodium Phosphate is widely used in laboratories to prepare phosphate buffer solutions, often in combination with Monosodium Phosphate to achieve the required pH.
Laboratory Reagent
Disodium Phosphate is used as a laboratory reagent in analytical, biochemical and research applications where phosphate ions or controlled pH conditions are required.
Biochemical and Research Applications
Disodium Phosphate may be used in selected biochemical, microbiological and research procedures involving phosphate-buffered systems.
Chemical and Industrial Applications
Buffering and pH Control
Disodium Phosphate may be used in selected chemical and industrial processes where phosphate-based buffering or pH adjustment is required.
Phosphate Source in Chemical Processing
It can serve as a source of phosphate ions in selected chemical reactions, manufacturing processes and formulation systems.
Specialty Chemical Formulations
Disodium Phosphate may be incorporated into selected specialty chemical formulations where phosphate functionality, buffering or pH control is required.
Water and Process Applications
Water-Treatment and Process Systems
Phosphate salts, including Disodium Phosphate, may be used in selected water-treatment and industrial process systems where phosphate chemistry or pH control is required. Suitability depends on the specific process conditions and applicable requirements.
Disodium Phosphate Specifications
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White, crystalline powder or granules |
| 2 | Assay (Purity) | Not less than 98.0% |
| 3 | Loss on Drying | Not more than 0.5% |
| 4 | pH (5% solution) | 8.0 – 9.5 |
| 5 | Solubility | Freely soluble in water |
| 6 | Chloride (Cl⁻) | Not more than 50 ppm |
| 7 | Sulphate (SO₄²⁻) | Not more than 150 ppm |
| 8 | Heavy Metals | Not more than 10 ppm |
| 9 | Iron (Fe) | Not more than 5 ppm |
| 10 | Lead (Pb) | Not more than 3 ppm |
| 11 | Arsenic (As) | Not more than 2 ppm |
| 12 | Residue on Ignition | Not more than 0.05% |
Disodium Phosphate Dodecahydrate IP Specification
Download Disodium Phosphate Dodecahydrate IP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | Colourless, transparent crystals; very efflorescent. |
| 2 | Solubility | Freely soluble in water, insoluble in Alcohol |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | Appearance of Solution | Solution is clear and colourless. |
| 6 | Arsenic | Not more than 2 ppm |
| 7 | Heavy Metals | Not more than 10 ppm |
| 8 | Iron | Not more than 20 ppm |
| 9 | Chlorides | Not more than 250 ppm |
| 10 | Sulphates | Not more than 600 ppm |
| 11 | Reducing Substances | Passes the test |
| 12 | Sodium Dihydrogen Phosphate | Passes the test |
| 13 | Water | 57.00% to 61.00% |
| 14 | Assay (On anhydrous basis) | Not less than 98.00% and not more than 101.00% |
Disodium Phosphate Anhydrous USP Specification
Download Disodium Phosphate Anhydrous USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White crystalline powder |
| 2 | Solubility | Freely soluble in water, insoluble in Alcohol |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | Insoluble substances | Not more than 0.4% |
| 6 | Chloride | Not more than 0.06% |
| 7 | Sulphate | Not more than 0.2% |
| 8 | Arsenic | Not more than 16 ppm |
| 9 | Loss on drying | Not more than 5.0% |
| 10 | Assay (On dried basis) | Not less than 98.00% to Not more than 100.50% |
Disodium Phosphate Monohydrate USP Specification
Download Disodium Phosphate Monohydrate USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White crystalline powder |
| 2 | Solubility | Freely soluble in water, insoluble in Alcohol |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | Insoluble substances | Not more than 0.4% |
| 6 | Chloride | Not more than 0.06% |
| 7 | Sulphate | Not more than 0.2% |
| 8 | Arsenic | Not more than 16 ppm |
| 9 | Loss on drying | 10.30%–12.00% |
| 10 | Assay (On dried basis) | Not less than 98.00% to Not more than 100.50% |
Disodium Phosphate Dihydrate USP Specification
Download Disodium Phosphate Dihydrate USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White crystalline powder |
| 2 | Solubility | Freely soluble in water, insoluble in Alcohol |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | Insoluble substances | Not more than 0.4% |
| 6 | Chloride | Not more than 0.06% |
| 7 | Sulphate | Not more than 0.2% |
| 8 | Arsenic | Not more than 16 ppm |
| 9 | Loss on drying | 18.50%–21.50% |
| 10 | Assay (On dried basis) | Not less than 98.00% to Not more than 100.50% |
Disodium Phosphate Heptahydrate USP Specification
Download Disodium Phosphate Heptahydrate USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White crystalline powder |
| 2 | Solubility | Freely soluble in water, insoluble in Alcohol |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | Insoluble substances | Not more than 0.4% |
| 6 | Chloride | Not more than 0.06% |
| 7 | Sulphate | Not more than 0.2% |
| 8 | Arsenic | Not more than 16 ppm |
| 9 | Loss on drying | 43.00%–50.00% |
| 10 | Assay (On dried basis) | Not less than 98.00% to Not more than 100.50% |
Disodium Phosphate Dodecahydrate USP Specification
Download Disodium Phosphate Dodecahydrate USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White crystalline powder |
| 2 | Solubility | Freely soluble in water, insoluble in Alcohol |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | Insoluble substances | Not more than 0.4% |
| 6 | Chloride | Not more than 0.06% |
| 7 | Sulphate | Not more than 0.2% |
| 8 | Arsenic | Not more than 16 ppm |
| 9 | Loss on drying | 55.00%–64.00% |
| 10 | Assay (On dried basis) | Not less than 98.00% to Not more than 100.50% |
Disodium Phosphate Anhydrous BP Specification
Download Disodium Phosphate Anhydrous BP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White or almost white powder; hygroscopic. |
| 2 | Solubility | Soluble in water; practically insoluble in ethanol (96 per cent). |
| 3 | Identification by Alkalinity | Solution is slightly alkaline. |
| 4 | Identification by Loss on Drying | Complies with the test for Loss on Drying. |
| 5 | Identification by Sodium | It gives reaction of Sodium. |
| 6 | Identification by Phosphate | It gives reaction of phosphate. |
| 7 | Appearance of Solution | Solution is clear and colourless. |
| 8 | Reducing Substances | The colour of the permanganate is not completely discharged. |
| 9 | Monosodium Phosphate | Not more than 2.5% |
| 10 | Chlorides | Not more than 200 ppm |
| 11 | Sulfates | Not more than 500 ppm |
| 12 | Iron | Not more than 20 ppm |
| 13 | Loss on Drying | Not more than 1.0% |
| 14 | Assay (On dried substance) | Not less than 98.00% and not more than 101.00% |
Disodium Phosphate Dihydrate BP Specification
Download Disodium Phosphate Dihydrate BP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White or almost white powder or colourless crystals. |
| 2 | Solubility | Soluble in water; practically insoluble in ethanol (96 per cent). |
| 3 | Identification by Alkalinity | Solution is slightly alkaline. |
| 4 | Identification by Loss on Drying | Complies with the test for Loss on Drying. |
| 5 | Identification by Sodium | It gives reaction of Sodium. |
| 6 | Identification by Phosphate | It gives reaction of phosphate. |
| 7 | Appearance of Solution | Solution is clear and colourless. |
| 8 | Reducing Substances | The colour of the permanganate is not completely discharged. |
| 9 | Monosodium Phosphate | Not more than 2.5% |
| 10 | Chlorides | Not more than 400 ppm |
| 11 | Sulfates | Not more than 0.1% |
| 12 | Iron | Not more than 40 ppm |
| 13 | Loss on Drying | 19.50% to 21.00% |
| 14 | Assay (On dried substance) | Not less than 98.00% and not more than 101.00% |
Disodium Phosphate Dodecahydrate BP Specification
Download Disodium Phosphate Dodecahydrate BP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | Colourless, transparent crystals; very efflorescent. |
| 2 | Solubility | Freely soluble in water; practically insoluble in ethanol (96 per cent). |
| 3 | Identification by Alkalinity | Solution is slightly alkaline. |
| 4 | Identification by Loss on Drying | Complies with the test for Loss on Drying. |
| 5 | Identification by Sodium | It gives reaction of Sodium. |
| 6 | Identification by Phosphate | It gives reaction of phosphate. |
| 7 | Appearance of Solution | Solution is clear and colourless. |
| 8 | Reducing Substances | The colour of the permanganate is not completely discharged. |
| 9 | Monosodium Phosphate | Not more than 2.5% |
| 10 | Chlorides | Not more than 200 ppm |
| 11 | Sulfates | Not more than 500 ppm |
| 12 | Iron | Not more than 20 ppm |
| 13 | Loss on Drying | 57.00% to 61.00% |
| 14 | Assay | Not less than 98.50% and not more than 102.50% |
Note: Additional test to be carried out as per customer requirements.
Disodium Phosphate Packing and Storage condition
Packing:
Packed in 25 kg / 50 kg HDPE bags with an inner LDPE liner for moisture protection.
Bulk packaging available upon request.
Storage:
Store in a cool, dry, and well-ventilated area, away from direct sunlight and incompatible substances.
Why Choose Chemignition for
Disodium Phosphate Supply?
Quality Assurance
Grade Compliance
Disodium Phosphate is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
Large-Scale Manufacturing and Export
Grade Compliance
Disodium Phosphate is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
