Key Properties of Disodium Phosphate
| Product Name: | Disodium Phosphate |
| Synonyms: | Sodium Hydrogen Phosphate, DSP |
| CAS No: | 7558-79-4 |
| Chemical Formula: | Na₂HPO₄ |
| Grade: | IP / BP / USP |
| Appearance: | White, crystalline powder or granules |
| Molar Mass: | 141.96 g/mol |
| Solubility: | Freely soluble in water, insoluble in alcohol |
| Melting Point: | Na₂HPO₄ (anhydrous) decomposes upon heating |
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WhatsappManufacturing process of Disodium Phosphate
Step 1: Raw Material Selection
- High-purity phosphoric acid and sodium carbonate are selected.
- Raw materials undergo strict quality checks for purity.
Step 2: Chemical Reaction & Processing
- Phosphoric acid reacts with sodium carbonate to form Disodium Phosphate solution.
- The solution is filtered and refined to remove impurities.
Step 3: Crystallization & Drying
- The solution is evaporated, crystallized, and dried to achieve the required purity.
Step 4: Quality Control & Testing
- The product is tested for assay, solubility, moisture content, and pH as per IP/BP/USP standards.
Step 5: Packaging & Storage
- Packed in HDPE bags or fiber drums to prevent contamination.
- Stored in a cool, dry place to maintain stability.
Applications of Disodium Phosphate
Pharmaceutical Industry
Medicinal Uses
Used as a pH buffer and electrolyte replenished.
Tablet Formulation
Used as an excipient in pharmaceutical preparations.
Food & Beverage Industry
Emulsifier & Stabilizer
Used in processed cheese and dairy products.
pH Regulator
Maintains acidity levels in food and beverages.
Water Treatment Industry
Boiler Water Treatment
Prevents scale formation in boilers.
Corrosion Inhibitor
Used in industrial cooling systems.
Industrial Applications
Detergents
Used in laundry detergents to improve performance.
Textile Processing
Acts as a softening and dispersing agent.
Metal Treatment
Used in phosphating solutions for corrosion resistance.
Technical Specifications of Disodium Phosphate
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White, crystalline powder or granules |
| 2 | Assay (Purity) | Not less than 98.0% |
| 3 | Loss on Drying | Not more than 0.5% |
| 4 | pH (5% solution) | 8.0 – 9.5 |
| 5 | Solubility | Freely soluble in water |
| 6 | Chloride (Cl⁻) | Not more than 50 ppm |
| 7 | Sulphate (SO₄²⁻) | Not more than 150 ppm |
| 8 | Heavy Metals | Not more than 10 ppm |
| 9 | Iron (Fe) | Not more than 5 ppm |
| 10 | Lead (Pb) | Not more than 3 ppm |
| 11 | Arsenic (As) | Not more than 2 ppm |
| 12 | Residue on Ignition | Not more than 0.05% |
Disodium Phosphate Dodecahydrate IP Specification
Download Disodium Phosphate Dodecahydrate IP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | Colourless, transparent crystals; very efflorescent. |
| 2 | Solubility | Freely soluble in water, insoluble in Alcohol |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | Appearance of Solution | Solution is clear and colourless. |
| 6 | Arsenic | Not more than 2 ppm |
| 7 | Heavy Metals | Not more than 10 ppm |
| 8 | Iron | Not more than 20 ppm |
| 9 | Chlorides | Not more than 250 ppm |
| 10 | Sulphates | Not more than 600 ppm |
| 11 | Reducing Substances | Passes the test |
| 12 | Sodium Dihydrogen Phosphate | Passes the test |
| 13 | Water | 57.00% to 61.00% |
| 14 | Assay (On anhydrous basis) | Not less than 98.00% and not more than 101.00% |
Disodium Phosphate Anhydrous USP Specification
Download Disodium Phosphate Anhydrous USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White crystalline powder |
| 2 | Solubility | Freely soluble in water, insoluble in Alcohol |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | Insoluble substances | Not more than 0.4% |
| 6 | Chloride | Not more than 0.06% |
| 7 | Sulphate | Not more than 0.2% |
| 8 | Arsenic | Not more than 16 ppm |
| 9 | Loss on drying | Not more than 5.0% |
| 10 | Assay (On dried basis) | Not less than 98.00% to Not more than 100.50% |
Disodium Phosphate Monohydrate USP Specification
Download Disodium Phosphate Monohydrate USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White crystalline powder |
| 2 | Solubility | Freely soluble in water, insoluble in Alcohol |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | Insoluble substances | Not more than 0.4% |
| 6 | Chloride | Not more than 0.06% |
| 7 | Sulphate | Not more than 0.2% |
| 8 | Arsenic | Not more than 16 ppm |
| 9 | Loss on drying | 10.30%–12.00% |
| 10 | Assay (On dried basis) | Not less than 98.00% to Not more than 100.50% |
Disodium Phosphate Dihydrate USP Specification
Download Disodium Phosphate Dihydrate USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White crystalline powder |
| 2 | Solubility | Freely soluble in water, insoluble in Alcohol |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | Insoluble substances | Not more than 0.4% |
| 6 | Chloride | Not more than 0.06% |
| 7 | Sulphate | Not more than 0.2% |
| 8 | Arsenic | Not more than 16 ppm |
| 9 | Loss on drying | 18.50%–21.50% |
| 10 | Assay (On dried basis) | Not less than 98.00% to Not more than 100.50% |
Disodium Phosphate Heptahydrate USP Specification
Download Disodium Phosphate Heptahydrate USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White crystalline powder |
| 2 | Solubility | Freely soluble in water, insoluble in Alcohol |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | Insoluble substances | Not more than 0.4% |
| 6 | Chloride | Not more than 0.06% |
| 7 | Sulphate | Not more than 0.2% |
| 8 | Arsenic | Not more than 16 ppm |
| 9 | Loss on drying | 43.00%–50.00% |
| 10 | Assay (On dried basis) | Not less than 98.00% to Not more than 100.50% |
Disodium Phosphate Dodecahydrate USP Specification
Download Disodium Phosphate Dodecahydrate USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White crystalline powder |
| 2 | Solubility | Freely soluble in water, insoluble in Alcohol |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by phosphate | It gives reaction of phosphate. |
| 5 | Insoluble substances | Not more than 0.4% |
| 6 | Chloride | Not more than 0.06% |
| 7 | Sulphate | Not more than 0.2% |
| 8 | Arsenic | Not more than 16 ppm |
| 9 | Loss on drying | 55.00%–64.00% |
| 10 | Assay (On dried basis) | Not less than 98.00% to Not more than 100.50% |
Disodium Phosphate Anhydrous BP Specification
Download Disodium Phosphate Anhydrous BP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White or almost white powder; hygroscopic. |
| 2 | Solubility | Soluble in water; practically insoluble in ethanol (96 per cent). |
| 3 | Identification by Alkalinity | Solution is slightly alkaline. |
| 4 | Identification by Loss on Drying | Complies with the test for Loss on Drying. |
| 5 | Identification by Sodium | It gives reaction of Sodium. |
| 6 | Identification by Phosphate | It gives reaction of phosphate. |
| 7 | Appearance of Solution | Solution is clear and colourless. |
| 8 | Reducing Substances | The colour of the permanganate is not completely discharged. |
| 9 | Monosodium Phosphate | Not more than 2.5% |
| 10 | Chlorides | Not more than 200 ppm |
| 11 | Sulfates | Not more than 500 ppm |
| 12 | Iron | Not more than 20 ppm |
| 13 | Loss on Drying | Not more than 1.0% |
| 14 | Assay (On dried substance) | Not less than 98.00% and not more than 101.00% |
Disodium Phosphate Dihydrate BP Specification
Download Disodium Phosphate Dihydrate BP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White or almost white powder or colourless crystals. |
| 2 | Solubility | Soluble in water; practically insoluble in ethanol (96 per cent). |
| 3 | Identification by Alkalinity | Solution is slightly alkaline. |
| 4 | Identification by Loss on Drying | Complies with the test for Loss on Drying. |
| 5 | Identification by Sodium | It gives reaction of Sodium. |
| 6 | Identification by Phosphate | It gives reaction of phosphate. |
| 7 | Appearance of Solution | Solution is clear and colourless. |
| 8 | Reducing Substances | The colour of the permanganate is not completely discharged. |
| 9 | Monosodium Phosphate | Not more than 2.5% |
| 10 | Chlorides | Not more than 400 ppm |
| 11 | Sulfates | Not more than 0.1% |
| 12 | Iron | Not more than 40 ppm |
| 13 | Loss on Drying | 19.50% to 21.00% |
| 14 | Assay (On dried substance) | Not less than 98.00% and not more than 101.00% |
Disodium Phosphate Dodecahydrate BP Specification
Download Disodium Phosphate Dodecahydrate BP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | Colourless, transparent crystals; very efflorescent. |
| 2 | Solubility | Freely soluble in water; practically insoluble in ethanol (96 per cent). |
| 3 | Identification by Alkalinity | Solution is slightly alkaline. |
| 4 | Identification by Loss on Drying | Complies with the test for Loss on Drying. |
| 5 | Identification by Sodium | It gives reaction of Sodium. |
| 6 | Identification by Phosphate | It gives reaction of phosphate. |
| 7 | Appearance of Solution | Solution is clear and colourless. |
| 8 | Reducing Substances | The colour of the permanganate is not completely discharged. |
| 9 | Monosodium Phosphate | Not more than 2.5% |
| 10 | Chlorides | Not more than 200 ppm |
| 11 | Sulfates | Not more than 500 ppm |
| 12 | Iron | Not more than 20 ppm |
| 13 | Loss on Drying | 57.00% to 61.00% |
| 14 | Assay | Not less than 98.50% and not more than 102.50% |
Note: Additional test to be carried out as per customer requirements.
Packing and Storage condition of Disodium Phosphate
Packing:
Packed in 25 kg / 50 kg HDPE bags with an inner LDPE liner for moisture protection.
Bulk packaging available upon request.
Storage:
Store in a cool, dry, and well-ventilated area, away from direct sunlight and incompatible substances.
Why Choose Chemignition for
Disodium Phosphate Supply?
Quality Assurance
Grade Compliance
Disodium Phosphate is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
Large-Scale Manufacturing and Export
Grade Compliance
Disodium Phosphate is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
