Key Properties of Potassium citrate
| Product Name: | Potassium Citrate |
| Synonyms: | Tripotassium citrate |
| CAS No: | 6100-05-6 |
| Chemical Formula: | C₆H₅K₃O₇ |
| Grade: | IP / BP / USP |
| Appearance: | White or almost white, granular powder or transparent crystals; hygroscopic. |
| Molar Mass: | 306.39 g/mol |
| Solubility: | Very soluble in water; practically insoluble in ethanol (96 per cent). |
| Melting Point: | Decomposes before melting |
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WhatsappPotassium citrate Manufacturing process
1. Raw Material Selection:
- Procure high-purity Citric Acid and Potassium Hydroxide / Potassium Carbonate as primary raw materials.
- Ensure all raw materials meet pharmaceutical (IP/BP/USP) or food-grade (FCC) quality standards.
2. Solution Preparation:
- Dissolve Citric Acid in purified water to prepare a citric acid solution.
- Separately, dissolve Potassium Hydroxide or Potassium Carbonate in purified water.
3. Reaction and Mixing:
- Gradually add the potassium solution to the citric acid solution under controlled conditions.
- Maintain stirring and temperature control to ensure complete reaction.
- Continuously monitor pH and concentration to achieve the desired Potassium Citrate solution.
4. Filtration:
- The reaction mixture is filtered to remove any undissolved impurities or solid particles.
- Use multi-stage filtration for high-purity product.
5. Concentration (Evaporation Process):
- The filtered solution is concentrated using evaporators to remove excess water.
- Control temperature and vacuum settings to prevent product degradation.
6. Crystallization:
- The concentrated solution is cooled gradually to induce crystallization of Potassium Citrate.
- Control cooling rate and agitation for uniform crystal formation.
7. Centrifugation & Drying:
- Crystals are separated using centrifugation or filtration.
- The wet product is dried in fluid bed dryers (FBD) or vacuum dryers to achieve the desired moisture content.
8. Milling & Sieving:
- The dried Potassium Citrate is milled and passed through a vibro sifter to obtain the required particle size distribution (PSD).
9. Quality Control & Testing:
- The final product undergoes rigorous quality control (QC) tests, including:
- Purity & Assay (IP/BP/USP/FCC standards)
- Moisture content
- pH and solubility
- Heavy metals & microbial limits
10. Packaging & Storage:
- The finished Potassium Citrate is packed in double-layer polybags inside HDPE drums or fiber drums.
- Labeled as per regulatory requirements and stored in a cool, dry place to maintain stability.
Potassium citrate Applications
Pharmaceutical Applications
Alkalising Agent in Pharmaceutical Formulations
Suitable pharmaceutical grades of Potassium Citrate may be used as an alkalizing agent in selected pharmaceutical formulations. Citrate is metabolized to bicarbonate, which can contribute to an alkalizing effect. The required grade and concentration depend on the intended formulation and applicable requirements.
Urinary Alkalinisation Formulations
Potassium Citrate is used in suitable pharmaceutical preparations intended for urinary alkalinisation. Pharmaceutical manufacturers should select the appropriate grade, dosage form and specification according to the intended product and regulatory requirements.
Potassium and Citrate Source
Potassium Citrate may serve as a source of potassium and citrate ions in selected pharmaceutical preparations where these components are required.
Buffering and pH Control
Potassium Citrate can be used in citrate-based buffer systems to help control and maintain pH in suitable pharmaceutical formulations and manufacturing processes.
Nutraceutical Applications
Potassium Source in Nutritional Formulations
Suitable grades of Potassium Citrate may be used as a source of potassium in selected nutritional and nutraceutical formulations. The required quantity and grade depend on the formulation and applicable regulatory requirements.
Mineral Supplement Formulations
Potassium Citrate can be incorporated into selected mineral supplement formulations where potassium supplementation is required. Manufacturers should use a grade appropriate for the intended product.
Food and Beverage Applications
Acidity Regulator and Buffer
Food-grade Potassium Citrate can function as an acidity regulator and buffering agent in suitable food and beverage formulations, helping manufacturers control acidity and maintain the desired pH.
Stabilizing and Formulation Applications
Potassium Citrate may be used in selected food formulations where citrate ions contribute to product stability, mineral-ion control or other functional properties.
Chemical and Industrial Applications
Buffer Preparation and pH Control
Potassium Citrate may be used in selected chemical processes and formulation systems where citrate-based buffering or pH control is required.
Citrate and Potassium Source
It can serve as a source of citrate and potassium ions in selected chemical reactions and manufacturing processes.
Chelating and Sequestering Applications
Citrate ions can interact with certain metal ions. Therefore, Potassium Citrate may function as a chelating or sequestering component in suitable chemical and industrial formulations.
Laboratory and Research Applications
Laboratory Reagent and Buffer Preparation
Potassium Citrate is used as a laboratory reagent and in selected buffer solutions for analytical, chemical and research applications. The required purity and concentration depend on the specific test method or experimental procedure.
Potassium citrate Specifications
Potassium Citrate IP Specification
Download Potassium Citrate IP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White, granular crystals or a crystalline powder; odourless; hygroscopic. |
| 2 | Solubility | Freely soluble in water, Practically insoluble in ethanol. |
| 3 | Identification by Potassium | It gives reaction of Potassium. |
| 4 | Identification by Citrate | It gives reaction of Citrate. |
| 5 | Appearance of Solution | Solution is clear and colourless. |
| 6 | Acidity or Alkalinity | Passes the test |
| 7 | Arsenic | Not more than 2 ppm |
| 8 | Heavy Metals | Not more than 10 ppm |
| 9 | Sodium | Not more than 0.3% |
| 10 | Chlorides | Not more than 100 ppm |
| 11 | Oxalate | Not more than 300 ppm |
| 12 | Sulphates | Not more than 150 ppm |
| 13 | Readily Carbonisable Substances | The solution is not more intensely coloured than reference solution |
| 14 | Water | 4.0% to 7.0% |
| 15 | Assay (On anhydrous basis) | Not less than 99.00% and not more than 101.00% |
Potassium Citrate BP Specification
Download Potassium Citrate BP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White or almost white, granular powder or transparent crystals; hygroscopic. |
| 2 | Solubility | Very soluble in water; practically insoluble in ethanol (96 per cent). |
| 3 | Identification by Potassium | It gives reaction of Potassium. |
| 4 | Identification by Citrate | It gives reaction of Citrate. |
| 5 | Appearance of Solution | Solution is clear and colourless. |
| 6 | Acidity or Alkalinity | Passes the test |
| 7 | Readily Carbonisable Substances | The solution is not more intensely coloured than reference solution |
| 8 | Chlorides | Not more than 50 ppm |
| 9 | Oxalates | Not more than 300 ppm |
| 10 | Sulfates | Not more than 150 ppm |
| 11 | Sodium | Not more than 0.3% |
| 12 | Water | 4.0% to 7.0% |
| 13 | Assay (On anhydrous substance) | Not less than 99.00% and not more than 101.00% |
Potassium Citrate USP Specification
Download Potassium Citrate USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | Colourless crystals or white, crystalline Powder. |
| 2 | Solubility | Freely soluble in water, Practically insoluble in ethanol. |
| 3 | Identification by Potassium | It gives reaction of Potassium. |
| 4 | Identification by Citrate | It gives reaction of Citrate. |
| 5 | Tartrate | No crystalline precipitate is formed. |
| 6 | Alkalinity | Passes the test |
| 7 | Loss on drying | 3.0 % – 6.0 % |
| 9 | Assay (On anhydrous basis) | Not less than 99.00% and Not more than 100.50 % |
Note: Additional test to be carried out as per customer requirements.
Potassium citrate Packing and Storage condition
Packing:
- Potassium Citrate is packed in HDPE drums, fiber drums, or kraft paper bags with inner double-layer polyethylene liners to ensure product stability.
- Standard packaging sizes include 25 kg or 50 kg bags/drums.
- Custom packaging options are available based on specific requirements.
Storage Conditions:
- Store in a cool, dry, and well-ventilated area away from moisture, heat, and direct sunlight.
- Keep the container tightly closed to prevent contamination and maintain product integrity.
- Recommended storage temperature: Below 30°C.
Why Choose Chemignition for
Potassium citrate Supply?
Quality Assurance
Grade Compliance
Potassium citrate is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
Large-Scale Manufacturing and Export
Grade Compliance
Potassium citrate is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
