Magnesium Trisilicate Overview

Magnesium Trisilicate is inorganic salt it is used as an antacid and Magnesium Trisilicate cure/reduces acidity in the Gastrointestinal tract (oral cavity, pharynx, esophagus, stomach, small intestine, large intestine, and anal canal). Chemignition is a leading manufacturer and exporter of Magnesium Trisilicate Active Pharmaceutical Ingredients (API) worldwide. They adhere to strict Quality Management Systems (QMS) to ensure compliance with Good Manufacturing Practices (cGMPs). This commitment to quality and regulatory standards ensures that the Magnesium Trisilicate produced by Chemignition is of the highest quality and efficacy.

Key Properties of Magnesium Trisilicate

Product Name: Magnesium Trisilicate
Synonyms: Dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane
CAS No: 14987-04-03
Chemical Formula: Mg₂O₈Si₃
Grade: IP/BP/USP
Appearance: White, fine powder
Molar Mass: 152.373 g/mol
Solubility: Insoluble in water and organic solvents, Soluble in gastric acid
Colour: White in colour
Density: 2.83 g/cm³

Manufacturing process of Magnesium Trisilicate

Before beginning the process operation, ensure the cleanliness of equipment, check the availability of utilities, and verify the availability of raw materials and packing materials.

Charge sodium silicate in the reactor and adding magnesium sulfate solution under stirring. The reaction is maintained at 50–60°C to form magnesium trisilicate. After the reaction, the precipitate is filtered using vacuum filtration and washed with deionized water to remove sodium sulfate.

The product is dried in a vacuum dryer at 60–70°C for 480–600 minutes. The dried product is milled to achieve uniform particle size and sieved through the specified mesh size.

Pack Magnesium Trisilicate in a clear poly bag and twist the mouth of the bag. Secure it with a PVC strip. Place this bag inside another poly bag, twist its mouth, and secure it with a PVC strip. Finally, place the sealed bag in an HDPE container. Store Magnesium Trisilicate in a tightly closed, light-resistant container at a temperature below 30°C.

Applications of Magnesium Trisilicate

Therapeutic Uses
Antacid for Gastric Acid Relief
Magnesium trisilicate is commonly used as an antacid to relieve symptoms of heartburn, acid indigestion, and stomach upset. It works by neutralizing excess stomach acid, providing relief from discomfort caused by acidity.
Gastrointestinal Protective Agent
In addition to neutralizing stomach acid, magnesium trisilicate forms a protective coating on the stomach lining, which helps to protect against gastric irritation caused by acid reflux, ulcers, and other digestive conditions.
Treatment of Dyspepsia
Magnesium trisilicate is used to treat dyspepsia (indigestion) by alleviating symptoms such as bloating, nausea, and discomfort in the upper abdomen. It promotes a calm, less acidic environment in the stomach, improving overall digestive health.

Industrial Uses
Pharmaceutical Formulations
Magnesium trisilicate is used in various oral pharmaceutical formulations, especially in antacid preparations. It is found in tablets, powders, and suspensions, often in combination with other active ingredients like magnesium hydroxide or aluminum hydroxide to enhance its therapeutic efficacy.
R&D and Formulation Development
Magnesium trisilicate is involved in research for developing advanced drug delivery systems, such as controlled-release formulations that extend the duration of action. Studies also focus on its potential role in combination therapies for treating gastric disorders, such as peptic ulcers and gastroesophageal reflux disease (GERD).

Technical Specifications of Magnesium Trisilicate

Sr.No. Test Specification
1 Description White, odorless, tasteless powder
2 Identification A) Mix about 500 mg with 10 mL of 3 N hydrochloric acid, filter, and neutralize the filtrate to litmus paper with 6 N ammonium hydroxide: the neutralized filtrate responds to the tests for Magnesium.
B) Prepare a bead by fusing a few crystals of sodium ammonium phosphate on a platinum loop in the flame of a Bunsen burner. Place the hot, transparent bead in contact with Magnesium Trisilicate, and again fuse: silica floats about in the bead, producing, upon cooling, an opaque bead with a web-like structure.
3 Water Content 17.0% to 34.0%
4 Soluble Salts Not more than 1.5%
5 Chloride Not more than 0.055%
6 Sulfate Not more than 0.5%
7 Free Alkali Not more than 1.0 mL of 0.10 N hydrochloric acid is required to discharge the pink color of phenolphthalein TS in 20 mL of the diluted filtrate prepared in the test for Soluble salts.
8 Arsenic Not more than 8 ppm
9 Heavy Metals Not more than 0.003%
10 Acid-Consuming Capacity One gram consumes not less than 140 mL and not more than 160 mL of 0.10 N hydrochloric acid
11 Assay for Magnesium Oxide (MgO) Not less than 20.0%
12 Assay for Silicon Dioxide (SiO₂) Not less than 45.0%
13 Ratio of SiO₂ to MgO Between 2.10 and 2.37

 

Note: Additional test to be carried out as per customer requirements.

Packing and Storage condition of Magnesium Trisilicate

Pack Magnesium Trisilicate in a clear poly bag and twist the mouth of the bag. Secure it with a PVC strip. Place this bag inside another poly bag, twist its mouth, and secure it with a PVC strip. Finally, place the sealed bag in an HDPE container. Store Magnesium Trisilicate in a tightly closed, light-resistant container at a temperature below 30°C.

MSDS - Magnesium Trisilicate

Download MSDS

Why Choose Chemignition for
Magnesium Trisilicate Supply?

Quality Assurance

Grade Compliance

Magnesium Trisilicate is manufactured in adherence to stringent global pharmaceutical standards.

In-House Quality Control

Each batch undergoes rigorous testing for purity, stability, and efficacy.

Regulatory Approvals

Certified for export and compliant with international regulatory requirements.

Large-Scale Manufacturing and Export

Grade Compliance

Magnesium Trisilicate is manufactured in adherence to stringent global pharmaceutical standards.

In-House Quality Control

Each batch undergoes rigorous testing for purity, stability, and efficacy.

Regulatory Approvals

Certified for export and compliant with international regulatory requirements.

How to Order Magnesium Trisilicate

For bulk orders or more information about Adapalene, contact our sales team today:
 
Email
info@chemignition.com
Phone
+91 8866558673

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    FAQs related to Magnesium Trisilicate API

    What is the purity level of Chemignition’s Magnesium Trisilicate?

    Our Magnesium Trisilicate API can be more then 99% pure and meets industry standards with high purity levels to ensure efficacy of products.

    How is Magnesium Trisilicate packaged and stored for optimal stability?

    Pack Magnesium Trisilicate in a clear poly bag and twist the mouth of the bag. Secure it with a PVC strip. Place this bag inside another poly bag, twist its mouth, and secure it with a PVC strip. Finally, place the sealed bag in an HDPE container. Store Magnesium Trisilicate in a tightly closed, light-resistant container at a temperature below 30°C.

    What regulatory certifications does your Magnesium Trisilicate comply with?

    Our Magnesium Trisilicate complies with major international regulatory standards, including FDA, GMP and ISO 9001.

    Can you provide batch-specific documentation and COAs (Certificates of Analysis)?

    Yes, we provide complete documentation and COAs for each batch to ensure transparency and quality.

    How do you ensure consistent supply and timely delivery of Magnesium Trisilicate?

    We have a reliable supply chain and efficient production processes to meet your timelines and ensure consistent delivery.

    What is the shelf life of your Magnesium Trisilicate API?

    Our Magnesium Trisilicate has a shelf life of up to 72 months when stored under recommended conditions.

    Do you offer custom formulations or concentrations of Magnesium Trisilicate?

    Yes, we can customize formulations to meet your specific product requirements.

    What is the therapeutic usage of Magnesium Trisilicate?

    Magnesium trisilicate is an inorganic salt used as an antacid. It helps reduce acidity in the gastrointestinal tract, including the oral cavity, pharynx, esophagus, stomach, small intestine, large intestine, and anal canal.

    What is the usage of Magnesium Trisilicate API?

    Magnesium Trisilicate API is used for manufacturing the following formulations: 250 mg and 500 mg oral tablets, 200 mg/5 mL oral suspension, 200 mg effervescent tablets, and 300 mg powder for oral solution.