Key Properties of Sodium citrate dihydrate
| Product Name: | Sodium Citrate Dihydrate |
| Synonyms: | Trisodium citrate dihydrate |
| CAS No: | 6132-04-3 |
| Chemical Formula: | C₆H₈Na₃O₇·2H₂O |
| Grade: | IP / BP / USP |
| Appearance: | White, granular crystals or a white, crystalline powder; odourless; slightly deliquescent in moist air. |
| Molar Mass: | 294.10 g/mol |
| Solubility: | Freely soluble in water, practically insoluble in ethanol (96 per cent). |
| Melting Point: | Decomposes before melting |
Inquiry
WhatsappManufacturing process of Sodium citrate dihydrate
Step 1: Raw Material Selection
- Citric acid and sodium carbonate (or sodium bicarbonate) are selected as raw materials.
- The raw materials are tested for purity and quality compliance.
Step 2: Neutralization Reaction
- Citric acid is dissolved in purified water to form a solution.
- Sodium carbonate or sodium bicarbonate is gradually added to the solution under controlled conditions.
- The reaction takes place, forming sodium citrate in solution form.
Step 3: Filtration
- The solution is filtered to remove any undissolved impurities or particulate matter.
- The filtrate is collected for further processing.
Step 4: Crystallization
- The purified sodium citrate solution is cooled gradually to induce crystallization.
- Controlled cooling helps in forming Sodium Citrate Dihydrate crystals.
Step 5: Centrifugation & Drying
- The formed crystals are separated using a centrifuge to remove excess water.
- The wet crystals are dried under controlled temperature to obtain Sodium Citrate Dihydrate.
Step 6: Milling & Sieving
- The dried product is milled and sieved to obtain a uniform particle size as per specifications.
Step 7: Quality Control & Testing
- The final product undergoes assay, purity, moisture content, pH, and microbial analysis to ensure compliance with pharmacopeial standards (IP/BP/USP/FCC).
Step 8: Packaging & Storage
- The final product is packed in HDPE drums, kraft paper bags, or polyethylene-lined bags as per customer requirements.
- Stored in a cool, dry place to prevent moisture absorption and maintain product stability.
Applications of Sodium citrate dihydrate
Technical Specifications of Sodium citrate dihydrate
Sodium citrate dihydrate IP Specification
Download Sodium citrate dihydrate IP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White, granular crystals or a white, crystalline powder; odourless; slightly deliquescent in moist air. |
| 2 | Solubility | Freely soluble in water, Practically Insoluble in ethanol. |
| 3 | Identification by Sodium | It give reaction of Sodium |
| 4 | Identification by Citrate | It give reaction of Citrate |
| 5 | Appearance of solution | Solution is clear and colourless |
| 6 | Acidity or Alkalinity | Passes test |
| 7 | Arsenic | Not more than 2 ppm |
| 8 | Heavy metals | Not more than 10 ppm |
| 9 | Chloride | Not more than 100 ppm |
| 10 | Oxalate | Not more than 300 ppm |
| 11 | Sulphate | Not more than 150 ppm |
| 12 | Tartrate | Passes the test |
| 13 | Readily carbonisable substance | Passes the test |
| 14 | Water content | 11.0 % to 13.0% |
| 15 | Assay (On anhydrous basis) | Not less than 99.00% and Not more than 101.00% |
Sodium citrate dihydrate BP Specification
Download Sodium citrate dihydrate BP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White or almost white, crystalline powder or white or almost white, granular crystals, slightly deliquescent in moist air. |
| 2 | Solubility | Freely soluble in water, practically insoluble in ethanol (96 per cent). |
| 3 | Identification by Sodium | It give reaction of Sodium |
| 4 | Identification by Citrate | It give reaction of Citrate |
| 5 | Appearance of solution | Solution is clear and colourless |
| 6 | Acidity or Alkalinity | Passes the test |
| 7 | Readily carbonisable substances | Passes the test |
| 8 | Chlorides | Not more than 50 ppm |
| 9 | Oxalates | Not more than 300 ppm |
| 10 | Sulfates | Not more than 150 ppm |
| 11 | Water content | 11.0 to 13.0% |
| 12 | Pyrogens | Passes the test |
| 13 | Assay (On anhydrous basis) | Not less than 99.00% and Not more than 101.00% |
Sodium citrate dihydrate USP Specification
Download Sodium citrate dihydrate USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White, granular crystals or a white, crystalline powder; odourless; slightly deliquescent in moist air. |
| 2 | Solubility | Freely soluble in water, Practically Insoluble in ethanol. |
| 3 | Identification by Sodium | It give reaction of Sodium |
| 4 | Identification by Citrate | It give reaction of Citrate |
| 5 | Tartrate | No crystalline precipitate is formed |
| 6 | Alkalinity | Passes the test |
| 7 | Water content | 10.0 % to 13.0 % |
| 8 | Assay (On anhydrous basis) | Not less than 99.00% and Not more than 100.50 % |
Packing and Storage condition of Sodium citrate dihydrate
Packing:
Sodium Citrate Dihydrate is available in 25 kg HDPE bags with an inner polythene liner to ensure protection from moisture and contamination. Custom packaging options are also available as per customer requirements.
Storage Conditions:
Store in a cool, dry, and well-ventilated area, away from moisture, direct sunlight, and incompatible substances.
Why Choose Chemignition for
Sodium citrate dihydrate Supply?
Quality Assurance
Grade Compliance
Sodium citrate dihydrate is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
Large-Scale Manufacturing and Export
Grade Compliance
Sodium citrate dihydrate is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
