Key Properties of Sodium citrate dihydrate
| Product Name: | Sodium Citrate Dihydrate |
| Synonyms: | Trisodium citrate dihydrate |
| CAS No: | 6132-04-3 |
| Chemical Formula: | C₆H₈Na₃O₇·2H₂O |
| Grade: | IP / BP / USP |
| Appearance: | White, granular crystals or a white, crystalline powder; odourless; slightly deliquescent in moist air. |
| Molar Mass: | 294.10 g/mol |
| Solubility: | Freely soluble in water, practically insoluble in ethanol (96 per cent). |
| Melting Point: | Decomposes before melting |
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WhatsappSodium citrate dihydrate Manufacturing process
Step 1: Raw Material Selection
- Citric acid and sodium carbonate (or sodium bicarbonate) are selected as raw materials.
- The raw materials are tested for purity and quality compliance.
Step 2: Neutralization Reaction
- Citric acid is dissolved in purified water to form a solution.
- Sodium carbonate or sodium bicarbonate is gradually added to the solution under controlled conditions.
- The reaction takes place, forming sodium citrate in solution form.
Step 3: Filtration
- The solution is filtered to remove any undissolved impurities or particulate matter.
- The filtrate is collected for further processing.
Step 4: Crystallization
- The purified sodium citrate solution is cooled gradually to induce crystallization.
- Controlled cooling helps in forming Sodium Citrate Dihydrate crystals.
Step 5: Centrifugation & Drying
- The formed crystals are separated using a centrifuge to remove excess water.
- The wet crystals are dried under controlled temperature to obtain Sodium Citrate Dihydrate.
Step 6: Milling & Sieving
- The dried product is milled and sieved to obtain a uniform particle size as per specifications.
Step 7: Quality Control & Testing
- The final product undergoes assay, purity, moisture content, pH, and microbial analysis to ensure compliance with pharmacopeial standards (IP/BP/USP/FCC).
Step 8: Packaging & Storage
- The final product is packed in HDPE drums, kraft paper bags, or polyethylene-lined bags as per customer requirements.
- Stored in a cool, dry place to prevent moisture absorption and maintain product stability.
Sodium citrate dihydrate Applications
Pharmaceutical Applications
Buffering Agent in Pharmaceutical Formulations
Suitable pharmaceutical grades of Sodium Citrate Dihydrate may be used as a buffering agent in oral, liquid and other pharmaceutical formulations. It helps maintain the required pH and supports formulation stability where citrate-based buffer systems are appropriate.
pH Adjustment and Control
Sodium Citrate Dihydrate may be used to adjust and control pH in selected pharmaceutical formulations and manufacturing processes. It is commonly used with citric acid to prepare citrate buffer systems.
Anticoagulant Applications
Sodium Citrate is used in suitable anticoagulant systems because citrate ions can bind calcium ions involved in the blood coagulation process. Pharmaceutical or medical applications require the appropriate grade, concentration and compliance with applicable requirements.
Pharmaceutical Excipient
Sodium Citrate Dihydrate can function as an excipient in selected pharmaceutical preparations where buffering, pH regulation or citrate-related functionality is required.
Food and Beverage Applications
Acidity Regulator and Buffer
Food-grade Sodium Citrate Dihydrate is used as an acidity regulator and buffering agent in suitable food and beverage formulations. It helps manufacturers control acidity and maintain the desired pH.
Emulsifying Salt
Sodium Citrate is used as an emulsifying salt in selected processed-food applications, particularly where control of protein and mineral interactions helps achieve the required texture and stability.
Flavour and Formulation Applications
Food manufacturers may use Sodium Citrate to regulate tartness and balance acidity in suitable beverages, confectionery and other food formulations.
Laboratory and Analytical Applications
Buffer Preparation
Laboratories use Sodium Citrate Dihydrate to prepare citrate buffer solutions for analytical, biochemical and research applications requiring controlled pH conditions.
Chelating Applications
Citrate ions can interact with certain metal ions, making Sodium Citrate useful in selected laboratory and analytical procedures where metal-ion binding is required.
Laboratory Reagent
Sodium Citrate Dihydrate is used as a laboratory reagent in analytical, biochemical and research applications according to the required purity and test method.
Chemical and Industrial Applications
pH Control and Buffer Systems
Sodium Citrate Dihydrate may be used in selected chemical and industrial processes where citrate-based buffering or pH control is required.
Chelating and Sequestering Applications
Sodium Citrate can function as a chelating or sequestering agent in suitable formulations by interacting with certain metal ions. Its suitability depends on the formulation and process conditions.
Chemical Formulation and Processing
Manufacturers may use Sodium Citrate Dihydrate as a citrate source or functional ingredient in selected chemical formulations and processing applications.
Sodium citrate dihydrate Specifications
Sodium citrate dihydrate IP Specification
Download Sodium citrate dihydrate IP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White, granular crystals or a white, crystalline powder; odourless; slightly deliquescent in moist air. |
| 2 | Solubility | Freely soluble in water, Practically Insoluble in ethanol. |
| 3 | Identification by Sodium | It give reaction of Sodium |
| 4 | Identification by Citrate | It give reaction of Citrate |
| 5 | Appearance of solution | Solution is clear and colourless |
| 6 | Acidity or Alkalinity | Passes test |
| 7 | Arsenic | Not more than 2 ppm |
| 8 | Heavy metals | Not more than 10 ppm |
| 9 | Chloride | Not more than 100 ppm |
| 10 | Oxalate | Not more than 300 ppm |
| 11 | Sulphate | Not more than 150 ppm |
| 12 | Tartrate | Passes the test |
| 13 | Readily carbonisable substance | Passes the test |
| 14 | Water content | 11.0 % to 13.0% |
| 15 | Assay (On anhydrous basis) | Not less than 99.00% and Not more than 101.00% |
Sodium citrate dihydrate BP Specification
Download Sodium citrate dihydrate BP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White or almost white, crystalline powder or white or almost white, granular crystals, slightly deliquescent in moist air. |
| 2 | Solubility | Freely soluble in water, practically insoluble in ethanol (96 per cent). |
| 3 | Identification by Sodium | It give reaction of Sodium |
| 4 | Identification by Citrate | It give reaction of Citrate |
| 5 | Appearance of solution | Solution is clear and colourless |
| 6 | Acidity or Alkalinity | Passes the test |
| 7 | Readily carbonisable substances | Passes the test |
| 8 | Chlorides | Not more than 50 ppm |
| 9 | Oxalates | Not more than 300 ppm |
| 10 | Sulfates | Not more than 150 ppm |
| 11 | Water content | 11.0 to 13.0% |
| 12 | Pyrogens | Passes the test |
| 13 | Assay (On anhydrous basis) | Not less than 99.00% and Not more than 101.00% |
Sodium citrate dihydrate USP Specification
Download Sodium citrate dihydrate USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White, granular crystals or a white, crystalline powder; odourless; slightly deliquescent in moist air. |
| 2 | Solubility | Freely soluble in water, Practically Insoluble in ethanol. |
| 3 | Identification by Sodium | It give reaction of Sodium |
| 4 | Identification by Citrate | It give reaction of Citrate |
| 5 | Tartrate | No crystalline precipitate is formed |
| 6 | Alkalinity | Passes the test |
| 7 | Water content | 10.0 % to 13.0 % |
| 8 | Assay (On anhydrous basis) | Not less than 99.00% and Not more than 100.50 % |
Note: Additional test to be carried out as per customer requirements.
Sodium citrate dihydrate Packing and Storage condition
Packing:
Sodium Citrate Dihydrate is available in 25 kg HDPE bags with an inner polythene liner to ensure protection from moisture and contamination. Custom packaging options are also available as per customer requirements.
Storage Conditions:
Store in a cool, dry, and well-ventilated area, away from moisture, direct sunlight, and incompatible substances.
Why Choose Chemignition for
Sodium citrate dihydrate Supply?
Quality Assurance
Grade Compliance
Sodium citrate dihydrate is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
Large-Scale Manufacturing and Export
Grade Compliance
Sodium citrate dihydrate is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
