Key Properties of Sodium Acetate
| Product Name: | Sodium Acetate |
| Available form: | 1. Sodium Acetate Anhydrous 2. Sodium Acetate Trihydrate |
| CAS No: | 127-09-3 and 6131-90-4 |
| Chemical Formula: | C₂H₃NaO₂ and C₂H₃NaO₂ ⋅ 3H₂O |
| Grade: | USP and IP / BP / USP |
| Available Pack size: | 25 kg, 50 kg, 100 kg, or customized |
| Available Documents: | COA, MSDS and TDS |
| Self life: | 5 Year |
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Manufacturing Process
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Applications
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Specifications
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Packing and Storage
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MSDS
Manufacturing process of Sodium Acetate
1. Reaction (Neutralization Process)
Acetic acid is taken in a reaction vessel, and sodium carbonate or sodium hydroxide is gradually added under controlled stirring.
The temperature is maintained between 50°C to 70°C to ensure complete neutralization.
The process continues until a clear sodium acetate solution is formed.
2. Filtration (Impurity Removal)
The sodium acetate solution is passed through a vacuum filter or centrifuge to remove insoluble impurities.
3. Evaporation (Concentration Process)
The filtered solution is heated in an evaporator at 80°C to 90°C under reduced pressure.
This step removes excess water, resulting in a highly concentrated sodium acetate solution.
4. Crystallization (Formation of Sodium Acetate Trihydrate)
The concentrated solution is cooled to 10°C to 20°C, leading to the crystallization of Sodium Acetate Trihydrate.
The crystals are collected using a centrifuge or vacuum filtration.
5. Dehydration (Conversion to Anhydrous Form)
The Sodium Acetate Trihydrate crystals are transferred to a drying oven or fluid bed dryer.
Heated at 120°C to 150°C under vacuum or dry air circulation to remove water molecules.
This results in the formation of Sodium Acetate Anhydrous.
6. Grinding & Sieving
The dried Sodium Acetate Anhydrous is milled and passed through a vibro sifter to achieve the desired particle size.
7. Final Packaging & Storage
The final Sodium Acetate Anhydrous powder is packed in moisture-proof HDPE bags or drums.
Stored in a cool, dry place to prevent moisture absorption.
Applications of Sodium Acetate
Technical Specifications of Sodium Acetate
Sodium Acetate Anhydrous USP Specification
Download Sodium Acetate Anhydrous USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White or almost white, crystalline powder or colourless crystals. |
| 2 | Solubility | Freely soluble in water, practically insoluble in ethanol (96 per cent) |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by Acetate | It gives reaction of Acetate. |
| 5 | Chloride | Not more than 350 ppm |
| 6 | Sulphate | Not more than 50 ppm |
| 7 | Calcium and Magnesium | Passes test |
| 8 | Potassium | Passes test |
| 9 | Aluminium* | Not more than 0.2 ppm (“*” Aluminium test applicable only when Sodium Acetate is intended for use in the preparation of dialysis solutions) |
| 10 | pH | 7.5 to 9.2 |
| 11 | Insoluble matter | Not more than 0.05% |
| 12 | Loss on drying | Not more than 1.0% |
| 13 | Assay (On dried basis) | Not less than 99.00% and not more than 101.00% |
Sodium Acetate Trihydrate IP Specification
Download Sodium Acetate Trihydrate IP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | Colourless crystals or a white, crystalline powder. |
| 2 | Solubility | Freely soluble in water, practically insoluble in ethanol (96 per cent) |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by Acetate | It gives reaction of Acetate. |
| 5 | Appearance of solution | Solution is clear and colourless |
| 6 | pH | 7.5 to 9.0 |
| 7 | Arsenic | Not more than 2 ppm |
| 8 | Calcium and Magnesium | Not more than 50 ppm, calculated as Ca |
| 9 | Heavy Metals | Not more than 10 ppm |
| 10 | Iron | Not more than 20 ppm |
| 11 | Chlorides | Not more than 250 ppm |
| 12 | Sulphates | Not more than 200 ppm |
| 13 | Aluminium* | Not more than 0.2 ppm (“*” Aluminium test applicable only when Sodium Acetate is intended for use in the preparation of dialysis solutions) |
| 14 | Reducing Substances | Passes the test |
| 15 | Loss on Drying | 39.0% to 40.5% |
| 16 | Assay (On dried basis) | Not less than 99.00% to not more than 101.0% |
Sodium Acetate Trihydrate BP Specification
Download Sodium Acetate Trihydrate BP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White or almost white, crystalline powder or colourless crystals. |
| 2 | Solubility | Very soluble in water; soluble in ethanol (96 per cent). |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by Acetate | It gives reaction of Acetate. |
| 5 | Appearance of solution | Solution is clear and colourless |
| 6 | pH | 7.5 to 9.0 |
| 7 | Reducing Substances | Passes the test |
| 8 | Chlorides | Not more than 200 ppm |
| 9 | Sulphates | Not more than 200 ppm |
| 10 | Aluminium* | Not more than 0.2 ppm (“*” Aluminium test applicable only when Sodium Acetate is intended for use in the preparation of dialysis solutions) |
| 11 | Calcium and Magnesium | Not more than 50 ppm, calculated as Ca |
| 12 | Iron | Not more than 10 ppm |
| 13 | Loss on Drying | 39.0% to 40.5% |
| 14 | Assay (on dried substance) | Not less than 99.00% to not more than 101.00% |
Sodium Acetate Trihydrate USP Specification
Download Sodium Acetate Trihydrate USP Specification
| Sr. No. | Test | Specification |
|---|---|---|
| 1 | Description | White or almost white, crystalline powder or colourless crystals. |
| 2 | Solubility | Freely soluble in water, practically insoluble in ethanol (96 per cent) |
| 3 | Identification by Sodium | It gives reaction of Sodium. |
| 4 | Identification by Acetate | It gives reaction of Acetate. |
| 5 | Chloride | Not more than 350 ppm |
| 6 | Sulphate | Not more than 50 ppm |
| 7 | Calcium and Magnesium | Passes test |
| 8 | Potassium | Passes test |
| 9 | Aluminium* | Not more than 0.2 ppm (“*” Aluminium test applicable only when Sodium Acetate is intended for use in the preparation of dialysis solutions) |
| 10 | pH | 7.5 to 9.2 |
| 11 | Insoluble matter | Not more than 0.05% |
| 12 | Loss on drying | 38.0% to 41.0%. |
| 13 | Assay (On dried basis) | Not less than 99.00% and not more than 101.00% |
Packing and Storage condition of Sodium Acetate
Packing:
Packed in 25 kg / 50 kg HDPE bags with inner liner.
Available in fiber drums or customized packaging as per customer requirements.
Tamper-proof and moisture-resistant packaging ensures product stability.
Storage:
Store in a cool, dry, and well-ventilated area away from moisture.
Keep the container tightly closed to prevent contamination.
Avoid exposure to direct sunlight and incompatible materials (such as strong acids).
Recommended storage temperature: Below 30°C.
Why Choose Chemignition for
Sodium Acetate Supply?
Quality Assurance
Grade Compliance
Sodium Acetate is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
Large-Scale Manufacturing and Export
Grade Compliance
Sodium Acetate is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
