Cloprostenol sodium Manufacturer, Exporter and Supplier

Cloprostenol sodium Overview

Cloprostenol Sodium is a synthetic prostaglandin F2α analogue used in veterinary medicine for the management of reproductive functions in livestock. It is primarily applied for estrus synchronization, luteolysis induction, and treatment of uterine disorders such as pyometra and endometritis. The product helps improve breeding efficiency and controlled reproductive programs in cattle, sheep, goats, and swine. Cloprostenol Sodium is intended exclusively for veterinary use and should be administered under the guidance of a qualified veterinarian.

Key Properties of Cloprostenol sodium

Product Name:	Cloprostenol Sodium
Synonyms:	Cloprostenol sodium salt; Prostaglandin F2α analogue
CAS No:	55028-72-3
Chemical Formula:	C₂₂H₂₈Cl₂NaO₆
Grade:	Veterinary / Pharmaceutical Grade
Appearance:	White to off-white crystalline powder
Molar Mass:	467.84 g/mol
Solubility:	Freely soluble in water; soluble in methanol

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Manufacturing process of Cloprostenol sodium

Step 1: Chemical Synthesis

The prostaglandin backbone is synthesized through multi-step organic reactions involving stereoselective transformations.
Critical steps include:
- Controlled chain elongation
- Introduction of halogenated phenyl group
- Formation of correct stereochemistry (very critical for activity)

Step 2: Salt Formation

The free acid form of cloprostenol is neutralized with sodium hydroxide or sodium salt reagents
This converts it into Cloprostenol Sodium, improving:
- Water solubility
- Stability for injectable formulations

Step 3: Purification

Purification using:
- Solvent extraction
- Crystallization
- Advanced chromatography (if required)
Impurities are controlled as per veterinary pharmacopeial standards

Step 4: Drying & Milling

Vacuum or tray drying under controlled temperature
Milling to achieve uniform particle size

Applications of Cloprostenol sodium

Therapeutic Uses

Estrus Synchronization

Induces luteolysis (regression of corpus luteum) Brings animals into heat at a predictable time Widely used in: Cattle Buffalo Sheep Goats Pigs

Induction of Luteolysis

Causes functional and structural regression of the corpus luteum Leads to a drop in progesterone levels Allows normal estrus cycle to resume

Treatment of Uterine Disorders

Used in conditions where luteolysis and uterine contraction are required: Pyometra Chronic endometritis Persistent corpus luteum Uterine infections with CL presence

Induction of Abortion (Veterinary Use Only)

Used under controlled veterinary supervision Effective in early to mid-pregnancy depending on species

Expulsion of Mummified or Macerated Fetus

Stimulates uterine contractions Helps in removal of retained fetal material

Post-Partum Reproductive Management

Assists uterine involution Helps restore normal reproductive cycles after calving

Technical Specifications of Cloprostenol sodium

Sr.No.	Test	Specification
01	Description	White to off-white crystalline powder
02	Solubility	Freely soluble in water; soluble in methanol
03	Identification	A) By IR: Infrared absorption spectrum of the sample should correspond to that of the Cloprostenol Sodium reference standard. B) By HPLC: The retention time of the principal peak in the sample chromatogram should match that of the standard preparation.
04	Water Content	Not more than 5.0%
05	pH (1% w/v solution)	7.0 – 8.5
06	Related Substances by HPLC	A) Any individual impurity: Not more than 0.5% B) Total impurities: Not more than 2.0%
07	Assay by HPLC	Not less than 98.0% and not more than 102.0% (on dried basis)
08	Residual Solvents	Complies with ICH Q3C limits

Note: Additional test to be carried out as per customer requirements.

Packing and Storage condition of Cloprostenol sodium

Pack Cloprostenol sodium in a glass vial. Place the vial inside a poly bag, twist its mouth, and secure it with a PVC strip. Insert this bag into a triple-laminated aluminum bag and seal it properly. Finally, place the sealed aluminum bag in an HDPE container. Store Cloprostenol sodium in a tightly closed, light-resistant container at a temperature of 2–8°C.

MSDS - Cloprostenol sodium

Why Choose Chemignition for
Cloprostenol sodium Supply?

Quality Assurance

Grade Compliance

Cloprostenol sodium is manufactured in adherence to stringent global pharmaceutical standards.

In-House Quality Control

Each batch undergoes rigorous testing for purity, stability, and efficacy.

Regulatory Approvals

Certified for export and compliant with international regulatory requirements.

Large-Scale Manufacturing and Export

Grade Compliance

Cloprostenol sodium is manufactured in adherence to stringent global pharmaceutical standards.

In-House Quality Control

Each batch undergoes rigorous testing for purity, stability, and efficacy.

Regulatory Approvals

Certified for export and compliant with international regulatory requirements.

How to Order Cloprostenol sodium

For bulk orders or more information about Adapalene, contact our sales team today:

info@chemignition.com

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+91 8866558673

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FAQs related to Cloprostenol sodium API

What is Cloprostenol Sodium used for?

Cloprostenol Sodium is used in veterinary medicine for estrus synchronization, induction of luteolysis, and treatment of reproductive disorders in livestock.

Is Cloprostenol Sodium for human use?

No. Cloprostenol Sodium is strictly for veterinary use only and should be administered by a qualified veterinarian.

Which animals are treated with Cloprostenol Sodium?

It is commonly used in cattle, buffalo, sheep, goats, swine, and horses under approved veterinary protocols.

How does Cloprostenol Sodium work?

It mimics prostaglandin F2α, causing regression of the corpus luteum, reducing progesterone levels, and triggering estrus and uterine contractions.

Is Cloprostenol Sodium GMP compliant?

Yes, it is manufactured under GMP conditions and supplied with batch-specific COA and regulatory documentation.