Key Properties of Travoprost
| Product Name: | Travoprost |
| Synonyms: | Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-4,4-difluorobutyl]cyclopentyl]hept-5-enoate |
| CAS No: | 157283-68-6 |
| Chemical Formula: | C₂₃H₃₄F₂O₅ |
| Grade: | USP/IP/IH |
| Appearance: | Colorless to slightly yellow viscous liquid |
| Molar Mass: | 500.6 g/mol |
| Solubility: | Insoluble in water, but it is soluble in organic solvents such as ethanol and methanol. |
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BroucherManufacturing process of Travoprost
Before starting the operation, ensure the cleanliness of equipment, availability of utilities, and confirmation of raw materials and packing materials.
Charge dichloromethane in glass pot and add prostaglandin derivatives and reagents for esterification. The reaction is maintained at 25–30°C for 360–480 minutes. After the reaction, the mixture is cooled to 0–5°C, and an anti-solvent is added to initiate crystallization.
The product is then filtered and washed with chilled anti-solvent. The final product is dried under vacuum at -20°C.
Pack Travoprost in a glass or polypropylene vial. Place the vial inside a poly bag, twist its mouth, and secure it with a PVC strip. Insert this bag into a triple-laminated aluminum bag and seal it properly. Finally, place the sealed aluminum bag in an HDPE container. Store Tafluprost in a tightly closed, light-resistant container at a temperature of -20°C to -10°C.
Applications of Travoprost
Technical Specifications of Travoprost
| Sr.No. | Test | Specification |
|---|---|---|
| 01 | Description | pale yellow to yellow color oil |
| 02 | Solubility | Freely soluble in methanol |
| 03 | Identification | A) By IR: Infrared absorption spectrum obtained from the sample should correspond to the Travoprost reference standard spectrum B) By HPLC: The retention time of the principal peak in the chromatogram of the sample preparation should match that of the standard preparation as obtained in assay test |
| 04 | Water Content | Not more than 1.0% |
| 05 | Specific Optical Rotation | +52° – +58° |
| 06 | Related Substances by HPLC | A) Travoprost related compound A: Not more than 0.20% B) Epoxide derivative: Not more than 0.40% C) 15-epi diastereomer: Not more than 0.10% D) 5,6 Trans isomer: Not more than 3.00% E) 15-keto derivative: Not more than 0.30% F) Any other individual impurity: Not more than 0.10% G) Total impurity: Not more than 4.0% |
| 07 | Assay by HPLC on anhydrous basis | Not less than 96.0% w/w to Not more than 102.0% w/w |
| 08 | Residual Solvents by GC | A) Dichloromethane: Not more than 600 ppm B) Toluene: Not more than 890 ppm C) Ethyl acetate: Not more than 5000 ppm D) THF: Not more than 720 ppm E) Methanol: Not more than 3000 ppm F) Ethanol: Not more than 5000 ppm G) Acetone: Not more than 5000 ppm |
Packing and Storage condition of Travoprost
Pack Travoprost in a glass or polypropylene vial. Place the vial inside a poly bag, twist its mouth, and secure it with a PVC strip. Insert this bag into a triple-laminated aluminum bag and seal it properly. Finally, place the sealed aluminum bag in an HDPE container. Store Tafluprost in a tightly closed, light-resistant container at a temperature of -20°C to -10°C.
Why Choose Chemignition for
Travoprost Supply?
Quality Assurance
Grade Compliance
Travoprost is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
Large-Scale Manufacturing and Export
Grade Compliance
Travoprost is manufactured in adherence to stringent global pharmaceutical standards.
In-House Quality Control
Each batch undergoes rigorous testing for purity, stability, and efficacy.
Regulatory Approvals
Certified for export and compliant with international regulatory requirements.
