| Product Name: | Adapalene |
| Synonyms: | 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid |
| CAS No: | 106685-40-9 |
| Chemical Formula: | C₂₈H₂₈O₃ |
| Grade: | USP |
| Appearance: | White to off-white powder or crystalline solid |
| Molar Mass: | 412.52 g/mol |
| Solubility: | Practically insoluble in water, but it is soluble in organic solvents such as ethanol, acetone, and tetrahydrofuran. |
Description
Chemignition leads the global market as a manufacturer and exporter of Adapalene Active Pharmaceutical Ingredients (API). They strictly follow Quality Management Systems (QMS) to ensure compliance with Good Manufacturing Practices (cGMPs), maintaining high-quality and efficacy in their Adapalene production.
Adapalene, a topical retinoid, treats acne vulgaris, a common skin condition affecting many individuals. It belongs to the retinoid class of drugs, derivatives of vitamin A, and is classified by generation, with later generations offering increased specificity for retinoic acid receptors.
Chemignition conducts dissolution, charcoalization, filtration, leaching, extraction, crystallization, and purification during the manufacturing of Active Pharmaceutical Ingredients (API) and specialty chemicals.
Pharmaceutical products like gels, lotions, and creams commonly use Adapalene API.
Developed in the late 1980s, Adapalene, a third-generation topical retinoid, gained FDA approval in 1996 for treating acne vulgaris under the brand name Differin. Designed to reduce side effects of earlier retinoids while providing effective acne treatment, a 0.3% gel formulation received approval for over-the-counter use in 2016, expanding its accessibility. It continues to be a key therapeutic option in dermatology due to its proven efficacy and safety.
Storage Conditions: Adapalene pack in a tightly closed polybag within a high-density polyethylene (HDPE) container, under nitrogen blanketing, at 2°C to 8°C.
