Sildenafil 100 mg: Active Ingredient, Uses, and Side Effects Explained

Sildenafil 100 mg is a well-known medication mainly used to treat erectile dysfunction (ED) and sometimes pulmonary arterial hypertension (PAH). Best recognized under brand names like Viagra and Revatio, it has helped millions worldwide improve their quality of life.

In this blog, we’ll explore the main active ingredient, how Sildenafil 100 mg works, its medical uses, and possible side effects you should be aware of.

Active Ingredient in Sildenafil 100 mg

The main active ingredient in Sildenafil 100 mg tablets is Sildenafil Citrate.

• Sildenafil Citrate is a chemical compound that belongs to a class of medicines called PDE5 (phosphodiesterase type 5) inhibitors.
• It helps relax blood vessels and increases blood flow to particular areas of the body, making it effective in treating conditions like erectile dysfunction and pulmonary hypertension.
• Chemically, Sildenafil Citrate is known as
  1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate.
• Each tablet contains 100 mg of Sildenafil Citrate as the active medicinal substance.

Other inactive ingredients in the tablet may include:

• Microcrystalline cellulose
• Calcium hydrogen phosphate
• Magnesium stearate
• Croscarmellose sodium
• Hypromellose
• Titanium dioxide
• Lactose

These inactive substances help with the tablet’s stability and absorption but do not directly affect the drug’s therapeutic action.

Manufacturers of Sildenafil Citrate (Active Ingredient)

The production of Sildenafil Citrate as an active pharmaceutical ingredient (API) is crucial for many pharmaceutical companies globally.

Some of the leading Sildenafil Citrate API manufacturers include:

• Chemignition Laboratory
  (A trusted manufacturer and exporter of Sildenafil Citrate, supplying high-quality APIs worldwide)

These manufacturers produce Sildenafil Citrate under stringent quality standards, following GMP (Good Manufacturing Practice) guidelines and certifications like FDA, ISO:9001 compliance. Their APIs are used by pharmaceutical brands across the globe to formulate Sildenafil tablets and other dosage forms.

How Does Sildenafil Work?

Sildenafil works by increasing blood flow to certain areas of the body.

For erectile dysfunction:

• During sexual stimulation, nitric oxide (NO) is released in the erectile tissue.
• This nitric oxide activates an enzyme called guanylate cyclase, which increases the levels of cyclic guanosine monophosphate .
• Increased cyclic guanosine monophosphate levels cause smooth muscle relaxation and enhance blood flow to the penis, facilitating an erection.
• Sildenafil Citrate works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which normally breaks down cyclic guanosine monophosphate.
• By blocking PDE5, Sildenafil Citrate helps maintain higher levels of cGMP, allowing an erection to persist longer during sexual stimulation.

For pulmonary hypertension:

• Sildenafil relaxes blood vessels in the lungs, helping blood flow more easily and reducing blood pressure within the lungs.

Medical Uses of Sildenafil 100 mg

1. Erectile Dysfunction (ED)

• Assists men in achieving and maintaining an erection sufficient for sexual activity.
• Requires sexual stimulation to work.

2. Pulmonary Arterial Hypertension (PAH)

• Sold under brand names like Revatio.
• Improves exercise capacity and symptoms by relaxing lung blood vessels.

Common Side Effects of Sildenafil 100 mg

While Sildenafil is generally safe, some individuals may experience side effects.

Mild to Moderate Side Effects:

• Headache
• Flushing (redness and warmth)
• Indigestion
• Nasal congestion
• Dizziness
• Visual disturbances (blurred vision, color tinge)
• Muscle pain or back pain

Serious Side Effects (Rare):

• Prolonged erection (priapism)
• Sudden vision loss (NAION)
• Sudden hearing loss
• Chest pain or irregular heartbeat

Seek immediate medical help if you experience serious side effects.

Precautions Before Taking Sildenafil 100 mg

Before using Sildenafil, you should consult your doctor, especially if:

• You have heart conditions or low blood pressure.
• You are taking nitrate medications.
• You have a history of vision problems.
• You are on multiple medications that may interact with Sildenafil.

Never self-medicate and always follow the prescribed dosage to avoid complications.

Final Thoughts

Sildenafil 100 mg is a reliable solution for erectile dysfunction and pulmonary hypertension when used properly. Understanding its active ingredient, how it works, approved uses, and possible side effects can help you use the medication more safely and effectively.

With leading manufacturers like Chemignition Laboratory and others producing high-quality Sildenafil Citrate, patients and pharmaceutical companies can access reliable, top-grade APIs for their medicinal needs.

Always consult a healthcare professional before starting Sildenafil to ensure it’s safe and appropriate for you.